Dynamic Structural Biology
Proteins are dynamic molecules. They move. They breathe. This movement enables their function. The diffUSE Project is building the methods, tools, and infrastructure to make protein motion visible, measurable, and usable — transforming how we discover drugs, design biology, and understand disease.
Reimagining How We Approach Science
We believe that unlocking protein dynamics requires not just new methods but also new ways we work together as scientists. By building openly, we aim to enable the collection of dynamic data at the scale and diversity needed to uncover the fundamental principles of biology.
The DiffUSE Hub
Our open science repository for unlocking protein dynamics, under active development. Notebook
The DiffUSE Logbook
An open science logbook for cataloging X-ray datasets, synchrotron notes, and unfiltered analyses. Blog
DiffUSE Dispatches
Blog posts from our scientists on methods, discoveries, and open science.
Latest Posts from our Scientists
To ensembles and beyond!
Sampleworks is a framework for integrating structural biology observables, structure predictors, and guidance to improve the modeling of conformational ensem...
Expanding The DiffUSE Project
Expanding The DiffUSE Project
Shake It Up!
MD simulations of changes in diffuse scattering depending on ligand binding
