Dynamic Structural Biology
Proteins are dynamic molecules. They move. They breathe. This movement enables their function. The diffUSE Project is building the methods, tools, and infrastructure to make protein motion visible, measurable, and usable — transforming how we discover drugs, design biology, and understand disease.
Reimagining How We Approach Science
We believe that unlocking protein dynamics requires not just new methods but also new ways we work together as scientists. By building openly, we aim to enable the collection of dynamic data at the scale and diversity needed to uncover the fundamental principles of biology.
Latest Posts from our Scientists
A Year (plus) of DiffUSE
Science progress over the first year-ish of the DiffUSE Project
WaterFlow: Predicting Ordered Water Molecule Positions on Protein Structures
A flow-matching model for predicting ordered water positions on protein structures, and what it reveals about the limits of the data we train it on.
qFitLatent: Learning the Motions of Multiconformers
Learning a latent representation of qFit multiconformers to capture the local dynamics that crystallography usually discards.
