Dynamic Structural Biology
Proteins are dynamic molecules. They move. They breathe. This movement enables their function. The diffUSE Project is building the methods, tools, and infrastructure to make protein motion visible, measurable, and usable — transforming how we discover drugs, design biology, and understand disease.
Reimagining How We Approach Science
We believe that unlocking protein dynamics requires not just new methods but also new ways we work together as scientists. By building openly, we aim to enable the collection of dynamic data at the scale and diversity needed to uncover the fundamental principles of biology.
The DiffUSE Hub
Our open science repository for unlocking protein dynamics, under active development. Notebook
The DiffUSE Logbook
An open science logbook for cataloging X-ray datasets, synchrotron notes, and unfiltered analyses. Blog
DiffUSE Dispatches
Blog posts from our scientists on methods, discoveries, and open science.
Latest Posts from our Scientists
Science in the Open: Open Development for Biomolecular Ensemble Generation
The diffUSE Project releases sampleworks, moving beyond open science to science in the open
The Tortured Proteins Department, Episode 14
The Tortured Proteins Department Podcast, Episode 14
Encoding Heterogeneity in mmCIF Files
Explicitly encoding hierarchical heterogeneity in mmCIF files
