Dynamic Structural Biology
Proteins are dynamic molecules. They move. They breathe. This movement enables their function. The diffUSE Project aims to unlock our understanding of protein dynamics at a scale never before possible. We are integrating the experimental methods, computational models, data standards, and infrastructure required to capture and interpret molecular motion across the proteome. Our goal is to make dynamic structural biology as foundational and indispensable as the Protein Data Bank has been for static structures.
Reimagining How We Approach Science
We believe that changing the ecosystem around unlocking protein dynamics will require not just new methods but also new ways we work together as scientists. We are experimenting with how we coordinate efforts and share our scientific process and results.
Latest Posts from our Scientists
DiffUSE January 2026 Retreat: From Coast to Coast, Diffuse Scattering Reproduces
A report on our January 2026 all-hands meeting
In the Cloud
Next steps in diffUSE MD simulations
Quarterly All-Hands Meeting Summary
A report on our October 2025 all-hands meeting
